Antibody product comprising n specific antibodies

Antikörperprodukt, umfassend n spezifische antikörper

Produit anticorps contenant n anticorps spécifiques

Abstract

Antikörperprodukt, umfassend n spezifische Antikörper, dadurch gekennzeichnet, dass a) die n spezifischen Antikörper jeweils einen Antikörper-Anteil von mindestens 6/n Gew.-% bezogen auf den Gesamt-Antikörper-Anteil des Antikörperproduktes besitzen, und b) 2, 3 oder mehr von den n spezifischen Antikörpern gegen Lipopolysaccharidexprimierende Mikroorganismen gerichtet sind, und c) der Gesamtanteil der n spezifischen Antikörper ≥7 Gew.-% bezogen auf den Gesamt-Antikörper-Anteil des Antikörperproduktes beträgt.
L'invention concerne un produit anticorps contenant n anticorps spécifiques, caractérisé en ce que a) les n anticorps spécifiques possèdent respectivement une fraction d'anticorps d'au moins 6/n % en poids par rapport à la fraction d'anticorps totale du produit anticorps, et b) 2, 3 ou plus des n anticorps spécifiques sont dirigés contre des micro-organismes exprimant le lipopolysaccharide, et c) la fraction totale des n anticorps spécifiques est ≥7 % en poids par rapport à la fraction d'anticorps totale du produit anticorps.
Antibody product comprising n specific antibodies, characterized in that a) the n specific antibodies each have an antibody content of at least 6/n% by weight based on the total antibody content of the antibody product and b) 2, 3 or more of the n-specific antibodies are directed against lipopolysaccharide-expressing microorganisms and c) the total content of the n specific antibodies is <span lang=EN-GB style='font-family:Symbol;color:navy'>³</span> 7% by weight based on the total antibody content of the antibody product.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (5)

    Publication numberPublication dateAssigneeTitle
    EP-0955061-A1November 10, 1999Medipharm CZ, s.r.o.Orales Produkt zur Vorbeugung und Therapie von gastroenterischen Infektionen bei Schweinen
    WO-0148018-A1July 05, 2001University Of ManitobaVaccins genetiques pour la production d'anticorps de jaune d'oeuf de poule diriges contre escherichia coli enterotoxinogene et d'autres pathogenes
    WO-2010125565-A2November 04, 2010Hadasit Medical Research Services And Development Ltd.Préparation d'immunoglobuline enrichie en anti-lps destinée au traitement et/ou à la prophylaxie d'un trouble pathologique
    WO-2012023051-A2February 23, 2012Immuron Ltd.Préparation d'immunoglobuline enrichie en anti-lps, destinée à être utilisée dans le traitement et/ou la prophylaxie d'un trouble pathologique
    WO-9216624-A1October 01, 1992The Common Services AgencyMonoclonal antibody against lps core

NO-Patent Citations (32)

    Title
    AKITA E M ET AL: "Comparison of four purification methods for the production of immunoglobulins from eggs laid by hens immunized with an enterotoxigenic E. coli strain", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 160, no. 2, 2 April 1993 (1993-04-02), pages 207 - 214, XP023974043, ISSN: 0022-1759, [retrieved on 19930402], DOI: 10.1016/0022-1759(93)90179-B
    AKITA E.M.; NAKAI S.: "Comparison of four purification methods for the production of immunoglobulins from eggs laid by hens immunized with an enterotoxogenic E. coli strain", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 160, no. 2, 1993, pages 207 - 214
    BIZHANOV G ET AL.: "A novel method, based on lithium sulfate precipitation for purification of chicken egg yolk immunoglobulin Y, applied to immunospecific antibodies against Sendai virus", SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE, vol. 31, no. 3, 2004, pages 121 - 130, XP002589471
    BIZHANOV G ET AL: "A novel method, based on lithium sulfate precipitation for purification of chicken egg yolk immunoglobulin Y, applied to immunospecific antibodies against Sendai virus", SCANDINAVIAN JOURNAL OF LABORATORY ANIMAL SCIENCE, SCANDINAVIAN SOCIETY FOR LABORATORY ANIMAL SCIENCE, DK, vol. 31, no. 3, 1 January 2004 (2004-01-01), pages 121 - 130, XP002589471, ISSN: 0901-3393
    E. NILLSON ET AL., J CHROMATOGR B ANALYTTECHNOL BIOMED LIFE SCI., vol. 856, no. 1-2, 2 June 2007 (2007-06-02), pages 75 - 80
    E. NILLSON ET AL., PEDIATR PULMONOL., 4 August 2008 (2008-08-04)
    E.M. IBRAHIM ET AL., VACCINE, vol. 26, 2008, pages 2073 - 2080
    GOEBEL A. ET AL., RHEUMATOLOGY, 2008
    H. KOLLBERG ET AL., PEDIATR PULMONOL., vol. 5, no. 6, 3 June 2003 (2003-06-03), pages 433 - 40
    H. SUZUKI ET AL., ALIMENT PHARMTHER, vol. 20, no. 1, 2004, pages 185 - 92
    H. YOKOYAMA ET AL., AMERICAN JOURNAL OF VETERINARY RESEARCH, vol. 59, no. 4, 1998, pages 416 - 420
    H. YOKOYAMA ET AL., THE JOURNAL OF VETERINARY MEDICAL SCIENCE, vol. 59, no. 10, 1997, pages 917 - 921
    H. YOKOYAMA ET AL., VACCINE, vol. 16, no. 4, 1998, pages 388 - 393
    HERNÄNDEZ-CAMPOS FJ ET AL.: "Purification of Egg Yolk Immunoglobulin (IgY) by Ultrafiltration: Effect of pH, lonic Strength, and Membrane Properties", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 8 December 2009 (2009-12-08), XP002678453, DOI: doi:10.1021/JF902964S
    HORIKOSHI TOSHIO ET AL: "IgG antibody from hen egg yolks: Purification by ethanol fractionation", JOURNAL OF FOOD SCIENCE, vol. 58, no. 4, 1993, pages 739 - 742, 779, XP002678305, ISSN: 0022-1147
    INFECT IMMUN., vol. 59, no. 11, 1991, pages 4161 - 4167
    J. SAKURAI ET AL.: "Purification and characterization of Clostridium perfringens beta toxin", TOXICON, vol. 25, no. 12, 1987, pages 1301 - 131, XP025852369, DOI: doi:10.1016/0041-0101(87)90008-0
    JAVIER HERNANDEZ-CAMPOS F ET AL: "Purification of Egg Yolk Immunoglobulin (IgY) by Ultrafiltration: Effect of pH, Ionic Strength, and Membrane Properties", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 58, no. 1, January 2010 (2010-01-01), pages 187 - 193, XP002678453, ISSN: 0021-8561
    K. YOKOYAMA ET AL., JOURNAL OF ORAL SCIENCE, vol. 49, no. 3, 2007, pages 201 - 6
    M. W. ODENTAAL: "Purification of the alpha toxin of Clostridium perfringens type A by ultra filtration and gel chromatography", ONDERSTEPOORT J. VET. RES., vol. 54, 1987, pages 39 - 43
    S. HAMADA ET AL., INFECT IMMUN, vol. 59, 1991, pages 4161 - 4167
    S. HAMADA ET AL., J GEN MICROBIOL, vol. 135, 1989, pages 335 - 44
    SCHADE R ET AL: "CHICKEN EGG YOLK ANTIBODIES (IGY-TECHNOLOGY): A REVIEW OF PROGRESS IN PRODUCTION AND USE IN RESEARCH AND HUMAN AND VETERINARY MEDICINE", ATLA. ALTERNATIVES TO LABORATORY ANIMALS, LONDON, GB, vol. 33, no. 2, 1 April 2005 (2005-04-01), pages 129 - 154, XP009057556, ISSN: 0261-1929
    SUZUKI H ET AL: "Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection.", ALIMENTARY PHARMACOLOGY & THERAPEUTICS JUL 2004 LNKD- PUBMED:15298626, vol. 20 Suppl 1, July 2004 (2004-07-01), pages 185 - 192, XP002678730, ISSN: 0269-2813
    TOSHIO, HORIKOSHI ET AL.: "lgG Antibody from Hen Egg Yolks: Purification by Ethanol", FRACTIONATION JOURNAL OF FOOD SCIENCE, vol. 58, no. 4, 1993, pages 739 - 742, XP002678305
    WAAGA-GASSER A. M. ET AL., INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERPEUTICS, 2009
    YOKOYAMA H ET AL: "A Two-Step Procedure for Purification of Hen Egg Yolk Immunoglobulin G: Utilization of Hydroxypropylmethylcellulose Phtalate and Synthetic Affinity Ligand Gel (Avid AL)", POULTRY SCIENCE, CHAMPAIGN, IL, US, vol. 72, 1 January 1993 (1993-01-01), pages 275 - 281, XP008091830, ISSN: 0032-5791
    YOKOYAMA H ET AL: "Effect of oral egg antibody in experimental F18+ Escherichia coli infection in weaned pigs.", THE JOURNAL OF VETERINARY MEDICAL SCIENCE / THE JAPANESE SOCIETY OF VETERINARY SCIENCE OCT 1997 LNKD- PUBMED:9362041, vol. 59, no. 10, October 1997 (1997-10-01), pages 917 - 921, XP002678452, ISSN: 0916-7250
    YOKOYAMA H ET AL: "Oral passive immunization against experimental salmonellosis in mice using chicken egg yolk antibodies specific for Salmonella enteritidis and S. typhimurium", VACCINE, ELSEVIER LTD, GB, vol. 16, no. 4, 1 February 1998 (1998-02-01), pages 388 - 393, XP004099299, ISSN: 0264-410X, DOI: 10.1016/S0264-410X(97)80916-4
    YOKOYAMA H ET AL: "Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 60, no. 3, 1 March 1992 (1992-03-01), pages 998 - 1007, XP002109373, ISSN: 0019-9567
    YOKOYAMA H. ET AL.: "A 2-step procedure for purification of hen egg-yolk immunoglobulin-G-utilization of hydroxypropylmethylcellulose phthalate and synthetic affinity ligand gel", POULTRY SCIENCE, vol. 72, 1993, pages 275 - 281, XP002741982, DOI: doi:10.3382/ps.0720275
    YOKOYAMA KYOSUKE ET AL: "Effects of egg yolk antibody against Porphyromonas gingivalis gingipains in periodontitis patients.", JOURNAL OF ORAL SCIENCE SEP 2007 LNKD- PUBMED:17928726, vol. 49, no. 3, September 2007 (2007-09-01), pages 201 - 206, XP002678729, ISSN: 1343-4934

Cited By (1)

    Publication numberPublication dateAssigneeTitle
    WO-2016166246-A1October 20, 2016Mat-Malta Advanced Technologies Limited, Julius-Maximilians-Universität WürzburgPredictive biomarkers of clinical response to anti-lps immunoglobulin treatment